Betaxolol and timolol. A comparison of efficacy and side

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1 [Book] (JSTOR) Mishima, Aesthetic Terrorist: An Intellectual Portrait by Andrew Rankin(self) 1 [Article] The Cancho i Ferrer - Solé model does not explain Zipf's Law(self) 1 [BOOK] The Skills Training Manual for Radically Open Dialectical Behavior Therapy: A Clinician’s Guide for Treating Disorders of Overcontrol By Thomas R. Lynch(self) 3 [BOOK] Quantum Mechanics, Volume 3: Fermions, Bosons, Photons, Correlations, and Entanglement by Claude Cohen Tannoudji, Bernard Diu, Frank Laloe(self) 1 [Article] Exploratory and Confirmatory Factor Analysis of an Urdu-version of the summary of Diabetes self-care Activities Measure (U-sDsCA)(self) 1 [Book] Advanced Asset Pricing Theory, by Chenghu Ma(self) 4 [Article] How open is OpenGLAM? Identifying barriers to commercial and non-commercial reuse of digitised art images(self) 2 [Article] RandomForest4Life: A Random Forest for predicting ALS disease progression(self) 1 [BOOK] Training in Interpersonal Skills: TIPS for Managing People at Work by SP Robbins and PL Hunsaker(self) 2 [Article] A Technological Review on Multilevel Matrix Converter for Wind Power Generation System(self) 1 [Book]Speaking of Writing: A Brief Rhetoric by Allegra Goodman; Michael Prince(self) 2 [Article] Human Rights and Tear Gas: The Question of Carter Administration Officials Opposed to the Shah -- Javier Gil Guerreo, British Journal of Middle Eastern Studies 43(3): 2016.(self) 2 [BOOK] Commercial Law Concentrate (Law Revision and Study Guide) by Eric Baskind (5th edition, Oxford University Press, 2019)(self) 1 [BOOK] Road Map for Revolutionaries: Resistance, Activism, and Advocacy for All(self) 5 [ARTICLE] Developing Symptoms: Noncommunicable Diseases Go Global(self) 4 [Book] Varieties of Secularism in Asia (Routledge) by Nils Bubandt, Martijn Van Beek(self) 2 7 [Book] Quantitative Modeling of Derivative Securities, by Peter Laurence(self) 2 [Book] 20 Years of Censored News by Carl Jensen and Project Censored(self) 2 [Book] Histoire de la rhétorique dans l'europe moderne (1450-1950), ed. Marc Fumaroli(self) 5 [Article] Topic (Reiko Vermuelen, 2016). Oxford Bibliographies.(self) 2 [Article]The effect of weather factors on restaurant sales(self) 4 [Book] Architectural Theory: Volume II - An Anthology from 1871 to 2005(self) 1 [Book] "La naissance de la grammaire dans l'Antiquité grecque" by Frédérique Ildefonse(self) 6 [ARTICLE] The Myth of Citizenship by Michael Ignatieff(self) 1 [BOOK] Time Sanctified the Book of Hours in Medieval Art and Life by Roger S Wieck (1988)(self) 1 [BOOK] Popular Culture and Law -Richard K. Sherwin(self) 2 [BOOK] The International Responsibility of the European Union: European and International Perspectives by Malcolm Evans and Panos Koutrakos; Hart Publishing (1st edition, 2013)(self) 5 [Article] Attributing Responsibility to International Organisations: Lessons from the EU–Singapore Investment Protection Agreement, European Investment Law and Arbitration Review Online by Christine Sim (Brill Nijhoff, 2018)(self) 1 [Article] Severe Autoimmune Adverse Events Post Herpes Zoster Vaccine: A Case-Control Study of Adverse Events in a National Database(self) 4 [ARTICLE] Empowerment Guarantee Act(self) 5 [BOOK][Chapters 1, 3, 6] Decentralization and Local Governance in Developing Countries: A Comparative Perspective(self) 1 [BOOK] Trends in Quorum Sensing and Quorum Quenching New Perspectives and Applications(self) 1 [Book] The Skills Training Manual for Radically Open Dialectical Behavior Therapy: A Clinician’s Guide for Treating Disorders of Overcontrol(self) 1 [Chapter] Odor Coding in the Olfactory Bulb(self) 11 [BOOK] 'The Oxford Handbook of Philosophy and Psychoanalysis' (2019) Edited by Richard G.T. Gipps and Michael Lacewing(self) 2 [Article] Artifacts - Maarten Franssen (Oxford Bibliographies)(self) 4 [article] An in Vivo comparison of hemostatic gelatin matrix products in porcine spleen biopsy punch model(self) 4 [Book] Media Studies 2.0, By William Merrin(self) 8 [Book] Gentrification by Loretta Lees, Tom Slater, Elvin Wyly (2008)(self) 1 [Article] Contrasting Neural Networks and 802.11 Mesh Networks(self) 4 [Book] Foreign Policy Objectives in European Constitutional Law by Joris Larik(self) 1 [Article] AI-enabled wargaming in the military decision making process (Schwartz PJ, O'Neill DV, Bentz ME, & al.)(self) 1 [Book] Forced Conversion in Christianity, Judaism and Islam edited by Mercedes García-Arenal and Yonatan Glazer-Eytan(self) 1 [Article] Contrasting Congestion Control and the Producer-Consumer Problem Using Pleaseman(self) 1 [Book] Data Visualization & Presentation With Microsoft Office(self) 5 [BOOK] Arts and Minds, Gregory Currie, 2004(self) 1 [article] Effect of Low-Dose Rapamycin on Senescence Markers and Physical Functioning in Older Adults With Coronary Artery Disease: Results of a Pilot Study(self) 4 [Chapter] from The Oxford Handbook of Fascism(self) 4 [Article] A Comparative Study on Bayesian Optimization(self) 3 [Article] The Plague in Literature and Myth by René Girard(self) 1 [Book] Shamanhood and Mythology : Archaic Techniques of Ecstasy and Current Techniques of Research : In Honour of Mihály Hoppál, celebrating his 75th Birthday(self) 4 [Article] Baksi, Sandipan 2020 Accurate Identification of Contradictions: Epidemics & Capitalism. Economic & Political Weekly 55(18), 2020.(self)NSFW 1 [Book] The Third Portuguese Empire, 1825-1975: A Study in Economic Imperialism By W. G. Clarence-Smith(self) 1 [Article] Colostomy prolapse(self) 4 [Thesis] The uses of the Dgongs Pa 'dus Pa'i Mdo in the development of the Rnying -ma school of Tibetan Buddhism(self) 1 [Article in french] 1940-1944: QUELLE POLITIQUE CHINOISE POUR L'ÉTAT FRANÇAIS?(self) 3 [Book] Bergman's Comprehensive Encyclopedia of Human Anatomic Variation(self) 4 [Book] The United Nations, Peace Operations and the Cold War By Norrie MacQueen(self) 1 [BOOK] The Oxford Handbook of Ethics of AI(self) 4 [ARTICLE] Women, Emancipation and Equality: Pandita Ramabai's Contribution to Women's Cause(self) 3 [Book] The apocalyptic symbolism of Andrej Belyj, by Samuel David Cioran(self) 1 [Book] The Masorah of Biblia Hebraica Stuttgartensia by Page H. Kelley & Daniel S. Mynatt(self) 1 [ARTICLE] Tobacco mosaic virus-like particles in mammalian cells inoculated with TMV ribonucleic acid(self) 4 [BOOK] The Oxford Handbook of Levinas(self) 5 [Book] (Brill) Examination of Pharisaic Traditions(self) 1 [Book] Modern Propaganda by J. M. del Hagen(self) 1 [ARTICLE] [Tobacco mosaic virus and chronic pulmonary diseases](self) 1 [ARTICLE] Recovery of culturable tobacco mosaic virus from sputum and thoracentesis fluids obtained from cigarette smokers with a history of pulmonary disease by LeClair, R A(self) 1 [CHAPTER] Phytochemical Compounds Targeting the Quorum Sensing System as a Tool to Reduce the Virulence Factors of Food Pathogenic Bacteria(self) 1 [BOOK] Vermeer's Camera: Uncovering the Truth Behind the Masterpieces by Philip Steadman(self) 1 [BOOK] Secret Knowledge: Rediscovering the Lost Techniques of the Old Masters BY David Hockney(self) 1 [ARTICLE] Teaching through modality strengths : concepts and practices(self) 3 [Book] The Theory of Shape by K.Borsuk(self) 1 [BOOK] Building Interpreting Skills by Duane Rumsey(self) 1 [book] Handbook of the Shapley Value by Algaba, Vito Fragnelli, Sánchez-Soriano(self) 0 [BOOK] Public Policy in Latin America. A Comparative Survey - John W. Sloan(self) 1 [Book] Spear-Won Land: Sardis from the King's Peace to the Peace of Apamea edited by Andrea M. Berlin and Paul J. Kosmin(self) 4 [ARTICLE] Durban: Road to Nowhere(self) 6 [Book] (Cambridge Core) Migration, Mobility and Multiple Affiliations - Edited by Rajan et al.(self) 1 [Book] Apparel Quality: A Guide to Evaluating Sewn Products(self) 1 [Textbook] Apparel Quality: A Guide to Evaluating Sewn Products(self) 4 [Book] Europe, 1890–1945 ByStephen J. Lee (Taylor francis)(self) 4 [Book] (BRILL) Indian Diaspora: Voices of the Diasporic Elders in Five Countries - Edited by Mehta & Singh(self) 2 [Article] The Impact of Technological and Market Uncertainty on Innovative Development Processes(self) 6 [Thesis] Algorithms and Properties of Distributionally Robust Optimization and Its Generalization(self) 4 [Book] [Cambridge] Contemporary Chinese Politics: New Sources, Methods, and Field Strategies(self) 1 [BOOK] Concise Public Speaking Handbook BY Steven A. Beebe and Susan J. Beebe(self) 6 [Book] (JSTOR) Introduction to the Primates by Daris R. Swindler(self) 1 [Book] Novel To Film: An Introduction to the Theory of Film Adaptation, by Brian McFarlane(self) 4 [ARTICLE] Hope at the End of the World: Creation Stories and Apocalypse in Alexis Wright's Carpentaria and The Swan Book, by Adelle L. Sefton-Rowston(self) 1 [BOOK] Reconceptualizing Indian Democracy: The Changing Electorate BY Chakrabarty, Bidyut, and Rajendra Kumar Pandey; Sage Publications Pvt. Limited, 2020(self) 3 [ARTICLE] Organizational Behavior in Megaprojects(self) 1 Testicular Microlithiasis: Is Sonographic Surveillance [Article] Necessary? Single Centre 14 Year Experience in 442 Patients With Testicular Microlithiasis(self) 6 [Book] Ancient legal thought : equity, justice, and humaneness from Hammurabi and the pharaohs to Justinian and the Talmud by Larry May(self) 2 [BOOK] Nanobrain: The Making of an Artificial Brain from a Time Crystal(self) 2 [Article] A Double-Masked Comparison of Betaxolol vs Timolol in the Treatment of Open-Angle Glaucoma Robert C. Allen, M.D. Ellen Hertzmark, M.A. Alexander M. Walker, M.D. David L. Epstein, M.D.(self) 1 [Book] The Boston Process Approach to Neuropsychological Assessment. A Practitioner's Guide by Ashendorf, Swenson & Libon(self) 1 [BOOK] Building Interpreting Skills by Duane Rumsey(self) 4 2 [Book] (JSTOR) The Economics of Oil and Gas by Xiaoyi Mu(self) 1 [Book] The Gender-Technology Relation. Contemporary Theory And Research: An Introduction (2018)(self) 1 [BOOK] ETHICS, PROFESSIONALISM, AND DECISION-MAKING FOR SIGN LANGUAGE INTERPRETERS(self) 1 [BOOK] The Interpreter's Quick Guide to Self-Employment(self) 1 [BOOK] The Professional Sign Language Interpreter's Handbook(self) 1 [Book] Oxford Textbook of Medicine 6th Edition ISBN-13: 978-0198746690, ISBN-10: 0198746695(self) 1 Needs Digitizing [Article] Bjorksten 1942, "Chemistry of duplication"(self) 7 [Article] some articles regarding akbar(self) 4 [Book] Social policy in times of austerity: Global economic crisis and the new politics of welfare by Kevin Farnsworth and Zoë Irving(self) 1 [Book] Transitions: Developing Chinese Fluency: Intermediate Chinese(self) 1 [BOOK] Economics of education by Dominic J.Brewer & Patrick J.McEwan(self) 1 [Article] Some Pharmacological Studies On Bufotenine And Bufotenidine; N A Pereira, I C Marins, H Moussatche(self) 9 [Article] Cromwell, Oliver by John Morrill from Oxford Dictionary of National Biography(self) 1 [Book] The King and the People: Sovereignty and Popular Politics in Mughal Delhi Abhishek Kaicker(self) 1 [BOOK] Power, Memory, Architecture: Contested Sites on India's Deccan Plateau, 1300-1600 Richard M. Eaton and Phillip B. Wagoner(self) 1 [Book] Hospitality Management: An Introduction by Eli Sampson(self) 1 [BOOK] The Interlinear Bible: Hebrew-English (4 Volume Set) (English, Hebrew and Greek Edition)(self) 1 [Request] [Article] An Intelligent Tutoring System Tool Combining Machine Learning and Gamification in Education(self) 1 [Book] Sacred Scents in Early Christianity and Islam, by Mary Thurlkill(self) 1 [ BOOK] The Interlinear Bible: Hebrew-English (4 Volume Set) (English, Hebrew and Greek Edition)(self) 4 [book] A Peril and a hope : the scientists' movement in America : 1945-47(self) 0 [Request] [Article] Uncertainties of Measurements in Room Acoustics(self) 1 [book] The Oxford Essential Dictionary of the U.S. Military(self) 4 [BOOK] 'The Camphor Flame: Popular Hinduism and Society in India - Revised and Expanded Edition' by C. J. FULLER, 2004(self) 1 [Request][Book] New Directions in Homotopy Theory - Contemporary Mathematics(self) 5 [Book] Peace Education Evaluation: Learning from Experience and Exploring Prospects by Celina Del Felice, Aaron Karako & Andria Wisler(self) 1 Meta The Real MVP of this whole subreddit, meet Alexandra Elbakyan. The web developer who created Sci-hub.(self) 0 [Request][Book] Nature Displaced, Nature Displayed: Order and Beauty in Botanical Gardens by Nuala Christina Johnson(self) 0 [Request][Book] Postnormal Conservation: Botanic Gardens and the Reordering of Biodiversity Governance by Katja Grötzner Neves(self) 8 [Request] [Article] "New considerations on Mamluk Heraldry"(self) 0 4 10 [Article] Malaina, Alvaro 2015 The Empire as Rhizome & Assemblage: Deleuze & Guattari's Reading of Hardt & Negri's Empire. The Global Studies Journal 8(2), 2015.(self)NSFW 6 0 3 . 5 1 [Book] Dynastic Lycia: A Political History of the Lycians and their Relations with foreign Powers, c. 545-362 B.C. by Antony. G. Keen(self) 1 [Book] Handbook of Multicultural Counseling [4th e.](self) 5 [Article] Different roles of distinct serotonergic pathways in anxiety-like behavior, antidepressant-like, and anti-impulsive effects (doi: 10.1016/j.neuropharm.2019.107703)(self) 4 [Article] The Tangential Impulse Water Wheel in California Gold Mining History(self) 4 [Book] (JSTOR) Imperial spaces: Placing the Irish and Scots in colonial Australia by Proudfoot, L., & Hall, D.(self) 6 [BOOK] Sons of the Soil: Migration and Ethnic Conflict in India by Myron Weiner(self) 0 [Chapter] MUSIC PATRONAGE IN THE SULTANATE OF GUJARAT: A SURVEY OF SOURCES With FRANÇOISE DELVOYE(self) 4 [Article] request: Creative workspaces – a fad or making real impact? doi: 10.1108/JCRE-09-2016-0029(self) 4 [article] PRE-ANNEXATION SULTANATE: ADMINISTRATION UNDER GUJARAT SULTANS(self) 1 [BOOKS] Party System Change in South India: Political Entrepreneurs, Patterns and Processes by Andrew Wyatt(self) 1 [Chapter] Court and State Evolution of a Regional Consensus, c. 1390–1511(self) 6 [BOOK] Understanding the Pentateuch as a Scripture(self) 1 [Book] Prehispanic Source Materials for the Study of Philippine History(self) 1 4 [BOOK] The Aleppo Codex: A True Story of Obsession, Faith, and the Pursuit of an Ancient Bible(self) 1 [Book] Proust/Warhol: Analytical Philosophy of Art by David Carrier(self) 1 [Book] Psychology 5th edition by Robert A. Baron, Girishwar Misra(self) 3 [BOOK] "The Popular Handbook of Archaeology and the Bible: Discoveries That Confirm the Reliability of Scripture(self) 2 [BOOK] "The Popular Handbook of Archaeology and the Bible: Discoveries That Confirm the Reliability of Scripture"(self) 4 [Book] Language, Education, and Neoliberalism (Flubacher and Del Percio, Eds.)(self) 5 [Book] The Metaphysics of Technology(self) 3 [Book] The Divided Economy of Mandatory Palestine, Jacob Metzer(self) 1 [book] Cycling and Cinema by Bruce Bennett(self) 4 [Book] (JSTOR) Diaspora Criticism by Sudesh Mishra(self) 4 [ARTICLE] Carmen Miranda and Brasilidade: Hollywood glamour and exoticism reinterpreted (ProQuest)(self) 1 [BOOK] INRA feeding system for ruminants(self) 2 [Article] Comparison of p450 Enzymes Between Cynomolgus Monkeys and Humans: p450 Identities, Protein Contents, Kinetic Parameters, and Potential for Inhibitory Profiles(self) 12 [Article] The Misunderstood Roots of International Order by James Goldgeier(self) 5 [Book] Cantonese: A Comprehensive Grammar (2nd edition)(self) 1 [Article] The culture of permadeath: Roguelikes and Terror Management Theory. Parker, Rob(self) 1 [Book] Environmental Ethics: An Anthology (Light and Rolston, eds.)(self) 2 [Book] IATA LAR Manual any edition(self) 1 [Chapter] 3 chapters from the book "Guru Gobind Singh (1666-1708) Master of the White Hawk"(self) 5 [ARTICLE] 'GNOSTIC LIBERALISM' George, Robert P. First Things: A Monthly Journal of Religion and Public Life; New York Iss. 268, (Dec 2016): 33-38 (no known doi)(self) 1 [book] An Invitation to Algebraic Numbers and Algebraic Functions - Franz Halter-Koch(self) 1 [Article] Stanford Journal of International Law Vol 22 (1986)(self) 7 [Book] The Rule of Unwritten International Law by Peter G. Staubach(self) 1 [Book] Good Work If You Can Get It: How to Succeed in Academia by Jason Brennan(self) 1 [BOOK] Indo-Persian relations : a study of the political and diplomatic relations between the Mughul Empire and Iran by Riazul Islam (1970)(self) 4 [ARTICLE] - The will to conservation: A Burkeian analysis of dust bowl rhetoric and American farming motives(self) 1 [Article] request ELT Journal Debate 2010 at IATEFL(self) 3 [ARTICLE] Quadriceps Tendon Graft for Anterior Cruciate Ligament Reconstruction: THE GRAFT OF THE FUTURE! - John W. Xerogeanes, M.D(self) 1 [Book] Technologie des Flugzeuges by Klaus Engmann(self) 7 [Book] The Oxford Handbook of Philosophy in Early Modern Europe(self) 4 [ARTICLE] Would anyone with access to Project Muse be able to help me with this?(self) 4 [Article] The Babaylan in Philippine History(self) 1 [Book] European Values (2017) by Pierre Bréchon and Frédéric Gonthier(self) 3 [ARTICLE] "Direct steering of de novo molecular generation with descriptor conditional recurrent neural networks" Panagiotis-Christos Kotsias, Josep Arús-Pous, Hongming Chen, Ola Engkvist, Christian Tyrchan & Esben Jannik Bjerrum. (2020)(self) 7 [Article] Cooking Literacy: Meringues as Culinary Scaffoldings(self) 1 [Book] The Comprehensive NCLEX-RN Review by ATI Nursing Education(self) 2 [Article] Anti-inflammatory activity of a fixed combination of probiotics and herbal extract in an in vitro model of intestinal inflammation by stimulating Caco-2 cells with LPS- conditioned THP-1 cells medium(self) 5 [Article] "A meta-analysis of the facial feedback literature: Effects of facial feedback on emotional experience are small and variable." Coles, N. A., Larsen, J. T., & Lench, H. C. (2019)(self) 3 [Article] schlesinger lb 2002 stalking homicide and catathymic process a case study(self) 4 [Article] c-Rel is a myeloid checkpoint for cancer immunotherapy(self) 4 [Article] Safe, Sane, and Consensual—Consent and the Ethics of BDSM, by Morten Ebbe Juul Nielsen(self) 1 [Book] Transnationalisation and Legal Actors: Legitimacy in Question (edited by By Bettina Lemann Kristiansen, Katerina Mitkidis, Louise Munkholm, Lauren Neumann, Cécile Pelaudeix)(self) 7 [Article] MUGHAL PAINTING, PATRONS AND PAINTERS S.P. Verma(self) 4 [Chapter] Chapter 6 Sixteenth-century manuscript painting in The Illustrated Baburnama(self) 1 [Book]Strong Soldiers, Failed Revolution The State and Military in Burma, 1962‒88(self) 1 [BOOK] The Lesser-known World of Mughal Emperor Jahangir BySom Prakash Verma(self) 5 [Article] Fasted Versus Nonfasted Aerobic Exercise on Body Composition(self) 5 [Article] Prevalence and Causes of Visual Impairment and Blindness Among Adult Chinese in Hong Kong - The Hong Kong Eye Study(self) 6 [BOOK] The Worm Farmer's Handbook: Mid- to Large-Scale Vermicomposting for Farms, Businesses, Municipalities, Schools, and Institutions by Rhonda Sherman(self) 4 [Article] Sedimentological Consequences of a Steady-State Ocean-Atmosphere(self) 1 [Article] The Ekphrastic Principle and the Still Movement of Poetry; or Laokoön Revisited(self) 10 [Book] Research Perspectives on English for Academic Purposes, by John Flowerdew and Matthew Peacock(self) 1 [Book] The Moral Argument by Paul Copan(self) 6 [Article] Effects of bisphenol A, an environmental endocrine disruptor, on the endogenous hormones of plants(self) 1 [Book] Iisashibun no Kenkyuu(self) 4 [Article] Prevalence and Associated Factors of Diabetic Retinopathy in Type 2 Diabetic Patients: A Hospital-Based Study(self) 1 [Article] Antiplatelet and Anticoagulation Treatment in Patients with Thrombocytopenia(self) 3 [Article] A Unified Nomenclature for Injectisome-Type Type III Secretion Systems(self) 7 [BOOK] Built on Sand: The Science of Granular Materials (The MIT Press)(self) 1 [book] Poverty and Deprivation in Europe by Brian Nolan and Christopher T. Whelan(self) 4 [Article] Transmission of microbial pathogens by cedar shoe trees by S. Woeste(self) 1 [BOOK] The Complete Guide to Working with Worms Using the Gardener's Best Friend for Organic Gardening and Composting Revised 2nd Edition by Wendy Vincent(self) 3 [Article] Wiley: "Real‐time flood forecasting based on a high‐performance 2D hydrodynamic model and numerical weather predictions" - Ming et al.(self) 3 [Book] Thicker than water: the origins of blood as symbol and ritual(self) 1 [BOOK] Humanities, Society, and Technology: Living With Change ( Robin Satterwhite, Janet Amirtharaj)(self) 1 [Book] A Social History of the Media: From Gutenberg to the Internet (3rd Edition). By Asa Briggs, Peter Burke(self) 1 [Book]The Oxford Handbook of Schopenhauer(self) 1 [Book] Convivial Toolbox: Generative Research for the Front End of Design(self) 4 [Book] (Brill) The Dispersion: A History of the Word Diaspora by Dufoix, Stéphane(self) 3 [Article] “The Pleasure Principle and Sexual Neurosis”, Viktor E. Frankl(self) 1 [BOOK] Communication, Digital Media, and Popular Culture in Korea: Contemporary Research and Future Prospects(self) 4 [CHAPTER] Carmen Miranda: From national star to global brand by Ana Rita Mendonça and Lisa Shaw(self) 1 [Book] Atheism from the Reformation to the Enlightenment by Michael Hunter and David Wootton(self) 0 [Request] [Book] Health Policy Issues: An Economic Perspective, 7th Edition(self) 1 [BOOK] Made in Korea: Studies in Popular Music (Routledge Global Popular Music Series)(self) 1 [BOOK] Proofs in Competition Math: Volume 1(self) 1 [BOOK] Psychology for the Other: Levinas, Ethics and the Practice of Psychology(self) 1 [Book] Magnum Contact Sheets by Kristen Lubben(self) 1 [BOOK] Routledge Handbook of East Asian Popular Culture(self) 4 [Book] Existential Semiotics - Eero Tarasti (2001)(self) 1 [Book] Intonation, structure prosodique et ondes cérébrales: introduction à l'analyse prosodique(self) 2 [Book] GIVE ME LIBERTY! VOL.2 5TH EDITION(self) 4 [Article] Optimal City Selection and Concert Tour Planning Based on Heuristic Optimization Methods and the Use of Social Media Analytics(self) 1 [BOOK] 'Performative politics and the cultures of Hinduism: Public uses of religion in Western India' by Raminder Kaur(self) 3 [Chapter] Logic and the Different Types of Question - James Somerville(self) 1 [Book] The Ephebic Inscriptions of the Fourth Century B.C. O.W. Reinmuth(self) 4 [Book] Scribal Wit Aramaic Mnemonics in the Leningrad Codex(self) 4 [Article] "Is there a Sophistic Ethics?" by Richard Bett (2002)(self) 5 [Book] Information Structure in Lesser-described Languages (2018)(self) 3 [Article] Unfilled Positions in the 2020 Radiation Oncology Residency Match: No Longer an Isolated Event(self) 4 [Book] Understanding Common Law Legislation: Drafting and Interpretation(self) 9 [Article] BnBeeEpi: An Approach of Epistasis Mining Based on Artificial Bee Colony Algorithm Optimizing Bayesian Network(self) 1 [Chapter] Title: Organization and function of the inorganic constituents of nuclei by Poulson and Bowen, 1952(self) 1 [BOOK] The Evolution and Social Impact of Video Game Economics- Casey B. Hart(self) 1 [Book] Egyptian Mythology: A Guide to the Gods, Goddesses and Traditions of Ancient Egypt by Geraldine Pinch(self) 3 [BOOK] Aristotle: Metaphysics Book Iota - Laura M. Castelli(self) 6 [Article] Virtues of Theft: Andre Techine's Thieves(self) 5 [CHAPTER] 'Love and Violence: Dialectical Reflections on the Phenomenology of the Crusade' Timo J. M. Slootweg(self) 1 [Book] Countervisions : Asian American Film Criticism(self) 4 [ARTICLE] Ecological functions and ecosystem services provided by Scarabaeinae dung beetles(self) 4 [ARTICLE] Wiley: River Research and Applications: Volume36, Issue4 Special Issue: Riverine landscapes, water resource development and management: A view from down under May 2020(self) 2 [Article] Intrinsic Valuing and the Limits of Justice: Why the Ring of Gyges Matters(self) 3 [BOOK] Nelson's Illustrated Bible Dictionary(self) 1 [BOOK] THE BIOSPHERE: PROTECTING OUR GLOBAL ENVIRONMENT (whole pdf please)(self) 7 [Book] Illuminating in Micrography, Dalia-Ruth Halperin(self) 6 [Book] From Perversion to Purity: The Stardom of Catherine Deneuve(self) 2 [Book] Effective Leadership and Management in Nursing(self) 4 [Article] Foster, John Bellamy (Editor) 2020 Monthly Review 72(1) 2020. (whole issue, please)(self) 1 [book] The Zofingia Lectures(self) 1 [Book] God's Phallus: And Other Problems for Men and Monotheism(self) 4 [book] America at War with Itself(self) 1 Needs Digitizing [Article] Thermal Conductivities of Gaseous Acetates(self) 1 [Book] Morality and Mathematics(self) 3 [BOOK] Explorations in Critical Criminology in Honor of William J. Chambliss - Dawn L. Rothe(self) 4 [Book] Algae Based Polymers, Blends, and Composites(self) 1 [Book] Nepal in crisis : growth and stagnation at the periphery by Piers M Blaikie(self) 1 [Book] Once a hermit kingdom : ethnicity, education, and national integration in Nepal by Tod Anthony Ragsdale(self) 0 . pdf: [Book] Software fault injection: inoculating programs against errors by Jeffrey M. Voas and Gary McGraw(self) 1 [Book] Pokhara : biography of a town by Jagannath Adhikari(self) 1 [Journal] Studies in Nepali history and society by Mandala Book Point(self) 7 [Article] Request: Anatomy of a persuasion schema: Targets, goals, and strategies (Rule, Bisanz, Kohn)(self) 4 [Chapter] Norms of Governance and Aspects of Administration Raziuddin Aquil(self) 5 [Book] Freud: An Intellectual Biography by Joel WhiteBook(self) 4 [Article] Efficacy and Tolerability of Tranylcypromine Versus Phenelzine: A Double-Blind Study in Antidepressant-Refractory Depressed Inpatients(self) 5 [Book] Feminist Theory: A Philosophical Anthology / Ann Cudd (Editor), Robin Andreasen (Editor)(self) 2 [BOOK] Schouler-Ocak, Meryam; Kastrup, M. Intercultural Psychotherapy For Immigrants, Refugees, Asylum Seekers and Ethnic Minority Patients.(self) 2 [Chapter] Les catégories et Les Catégories by Jonathan Barnes(self) 1 [Book] Constitutional law by JN pandey(self) 4 [Article] A Meta-Analytic Review of Two Modes of Learning and the Description-Experience Gap Dirk Wulff(self) 5 [Book] Cellular and Molecular Immunology, 9th Edition(self) 6 [Article] Energy Release Rate Approximation for Small Surface Cracks in Three-Dimensional Domains Using the Topological Derivative(self) 1 [book] Cognitive, emotive and ethical aspects of decision making and humans and in artificial intelligence, volume II(self) 1 [Book] The Seventh Million: The Israelis and the Holocaust(self) 2 [BOOK] International Organizations Politics, Law, Practice - Ian Hurd(self) 1 [Article] Methylphenidate as Treatment for Clozapine-Induced Sedation in Patients with Treatment-Resistant Schizophrenia.(self) 6 [Book] Social Background of Indian Nationalism by A. R. Desai(self) 1 [Book] Human Geography: A Short Introduction by John Rennie Short(self) 4 [Article] Dai, Qingfeng, et.al (2017): 'Compact notch slot antenna with quasi-isotropic radiation for UHF RFID tags', IEEE(self) 4 [book] The Oxford Handbook of New York State Government and Politics(self) 5 [Article] Foster, John Bellamy 2001 Imperialism and "Empire". Monthly Review 53 (7), 2001.(self)NSFW 1 [Book] Sintaxis y morfología de la lengua española(self) 5 [Article] On Being a Transamorous Man by G Nicholson(self) 8 [Article] Forensic analysis of android mobile devices(self) 5 [Chapter] "Concept, class, and category in the tradition of Aristotle" by J. P. Sutcliffe(self) 1 [Chapter] "Product Class 9: Benzo-1,2-, Benzo-1,4-, Naphtho-1,2-, and Naphtho-1,4-quinone Imines and Diimines"(self) 1 [Book] Beginning Modern Korean: An Interactive Approach(self) 5 [Book] Lovers of God Sufism and the Politics of Islam in Medieval India ByRaziuddin Aquil(self) 1 [Chapter] Butuan in the pre-colonial Southeast Asian international system(self) 4 [book] Handbook of Financial Risk Management by Thierry Roncalli(self) 1 [Article] Trade and Politics in Mindanao-Sulu, Moluccas and Bornay (Brunei), 14th-16th Centuries(self) 4 [Article] Looking for this paper(self) 4 [Book] Women and the Puranic Tradition in India ByMonika Saxena(self) 4 [Book] Spinoza on Reason, Passions, and the Supreme Good(self) 8 [Article] We Acquire Vocabulary and Spelling by Reading: Additional Evidence for the Input Hypothesis(self) 1 [Book] Britain and the Seventy Years War, 1744-1815 by Anthony Page(self) 2 [Article] Passive load-deformation properties of human temporal muscle(self) 1 [Book] Grounded theory: a practical guide (2nd. edition). 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Abelian logic (from A to Z)(self) 1 [Book Chapter] Meyer, R.K., Slaney, J.K. 1989. Abelian logic from A to Z.(self) 1 [book] Santiago, A First Course in Dimensional Analysis(self) 1 [BOOK] 'Pagans and Christians in the City: Culture Wars from the Tiber to the Potomac' by Steven D. Smith, Grand Rapids, Michigan : William B. Eerdmans Publishing Company, 2018(self) 5 [Article] The perception of musical rhythms + H. Christopher Longuet-Higgins and Christopher S. Lee(self) 1 [Book] The resilience machine; Jim Bohland, Simin Davoudi, Jennifer L. Lawrence(self) 1 [Book] Law and Social Theory, by Reza Banakar; Max Travers(self) 4 [Book] Living Mirrors: Infinity, Unity, and Life in Leibniz's Philosophy(self) 1 [Book] Digital Preservation for Libraries, Archives, and Museums (Second Edition)(self) 2 [Book] Arab Cinema: History and Cultural Identity (Viola Shafik, 2007, New Revised Edition)(self) 1 [Book] Gold For The Sultan by C.G.A. 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Juniper Publishers- JOJ Ophthalmology

Abstract

The endogenously generated small nonapeptide bradykinin (BK) is often associated with inflammation, edema and pain amongst many other functions and pathologies. However, the latter aspects pertain to locally produced BK from circulating plasma precursor polypeptide kinninogen (KNGN). Recent work in ocular tissues and cells have a revealed a novel local synthesis of BK and other kinins from tissue-derived KNGN via action of kallikrien enzymes, quite independent from the blood-derived polypeptide. Furthermore, the whole kininergic system machinery including local KNGN, kallikrein enzymes to generate kinins from KNGN, two sub-types of kinin receptors (Bj-and B2-receptors), and the complete signal transduction pathways coupled to these receptors have been mapped out. Additional work has highlighted a number of downstream signaling and other biological responses that ensue following activation of Ba- and B2 receptors in human ocular cells and tissues. One key aspect to be discussed in detail in this review is the novel finding that BK, peptidergic BK analogs, and especially non-peptide mimetics of kinins (e.g. FR-199097; BKA78), profoundly lower and control intraocular pressure in a number of species, including ocular hypertensive (OHT) monkeys. These novel observations strongly suggest that kinin agonists represent a novel class of ocular hypotensive agents that could be of immense value in treating OHT associated with primary open-angle glaucoma (POAG) and perhaps other forms of glaucoma.

Ocular Hypertension Associated with Glaucoma

At a simplistic level, our knowledge has advanced to a point where it is now clear that elevated intraocular pressure (IOP) results from a fundamental imbalance between the generation of aqueous humor by the ciliary body and its efflux from the anterior chamber of the eye via one of two pathways [1-3]. The most physiologically relevant mechanism of AQH drainage involves the IOP-dependent outflow via the trabecular mesh work (TM) and Schlemm's canal (SC) route [1-3]. The lesser utilized pathways under normal conditions are the uveoscleral [1-3] and ocular lymphatic [4] pathways, but the latter can be engaged by certain drugs such as FP-class prostaglandin analogs (FPGAs) like latanoprost and tafluprost [1-6]. The chronically increased IOP, a condition generally termed as ocular hypertension (OHT), caused by blockage of the AQH drainage TM/SC pathways [7] during the aging process or due to ocular inflammation and deposition of various debris, along with apoptotic death of retinal ganglion cells. can lead to a clinically defined disease called glaucoma [8-10]. This high IOP distressfully distends and traumatizes the whole Whilst, glaucoma is painless and otherwise asymptomatic globe and initiates the death of RGCs and/or breakage of RGC axons at the back of the eye. These elements then cause a retrograde demise of the RGCs leading to severing of nerve fibers connecting the retina to the brain [11-13]. Many deleterious neurotoxic elements (e.g. high levels of extruded glutamate, endothelin, inflammatory cyto-and chemo-kines, noxious gases (e.g. nitric oxide; hydrogen sulfide)) and proteolytic enzymes (e.g. caspases and matrix metalloproteinases) released by activated macrophages [12-19], injured RGCs and interneurons are the culprits responsible for such neurotoxicity/chemically-induced axotomy of the RGCs. Hypoxia and ischemia [20,21] are also involved in the initiation phase of vascular dysfunction-induced death of RGCs since the thinning of the optic nerve at the level of the optic nerve head (ONH) forces the retinal blood vessels attached to the optic nerve to bend thereby restricting blood supply to the retina. While this progressive loss of RGCs occurs over several decades, if OHT is not treated to reduce the IOP the resulting glaucomatous optic neuropathy causes severe visual impairment, reduction of visual acuity and visual field and eventually results in irreversible blindness. Although many forms of glaucoma exist (e.g. open-angle glaucoma; closed-angle glaucoma; exfoliation glaucoma; myopic glaucoma) [8,9,22-26], the most prevalent is primary open-angle glaucoma (POAG) [26-28]. Behind cataracts, POAG is the second leading cause of blindness afflicting several millions of patients. It is estimated that by 2020, the global glaucoma-related blindness will reach ~80 million [26-28]. Elevated IOP and advancing age are the two major risk factors associated with POAG even though genetic factors [26] and race (especially African and Asian heritage) [29], myopia, diabetes and oxidative stress [30-36] and various vascular irregularities and dysfunctions [20,22], and intracranial cerebrospinal pressure [37,38] have been also linked to the development of POAG. The seriousness of POAG is often underestimated since it causes no overt discomfort or pain to the patient and insidiously progresses unnoticed over time. Considerable damage to the retina [33-36] and optic nerve and optic nerve head (ONH) [14,29,39-41] continues unyieldingly leading to scotomatous damage that manifests as loss of peripheral vision followed by a "tunnel vision" syndrome, thereby finally signaling the demise of ~40% of the original million RGCsof the patient and equivalent loss of connections to the brain and visual cortex [8,9,42-45]. Those lost or dying RGCs cannot be resuscitated and their axonal connections revived [46-48], and if left untreated the glaucomatous optic neuropathy due to OHT and oxidative /neurotoxic elements would claim the remaining RGCs causing total blindness [49-53].
Data are mean±SEM uses a [Ca2+]I mobilization assay in cells derived from several different human donors' eyes. h-tNPE cells are SV40-virus- immortalized human non-pigmented ciliary epithelial cells derived from human ciliary epithelium that respond just like normal primary NPE cells. [145,146,157]
A number of treatment options have been developed to deal with POAG-associated OHT including ocular hypotensive medications [1-3,54-56], laser therapy and surgical interventions [57-64]. Unfortunately, as is the case with most drugs and surgical procedures, these treatment modalities have numerous side-effects (e.g. Burning and stinging, foreign- body sensation, brow-ache, ocular surface dryness, pulmonary hypertension and bradycardia, etc.), and adverse complications associated with them [1-3,54,55]. Additionally, poor compliance [65] and adherence to prescribed topical ocularly administrated medications by the OHT POAG patients (due to forget fulness, poor dexterity,lack of symptomatic pain or other cues due to OHT, poor understanding of the treatment regimen, and perhaps due distrust, etc.) contributes to the progression of the disease process. Similarly, laser therapies, although effective at the beginning, lose their efficacy over time [57-62]. Reports have surfaced that indicate that POAG/ OHT is only controlled in ~50% of patients who received laser treatment, and indeed due to scarring,the procedure often needs repeating within one-five years [57-64]. Indeed, such lasering and filtration procedures also have certain risks of complications and adverse events associated with them. Thus, there remains a continued unmet medical need to discover new and improved eye drop- medications and other novel surgical techniques to help the OHT/POAG patients mitigate and treat their underlying glaucomatous optic neuropathy caused by elevated IOP. To this end, a better understanding of the many complex pathways involved in AQH dynamics [4,7-10] has culminated in the discovery and development of many novel targets and ligands [13,54,55] that can modulate IOP via these targets to accomplish a level of homeostasis of AQH production and drainage. In order to address poor patient compliance, a number of innovations leading to sustained drug-release devices (e.g. implants, punctal plugs or contact lenses) [60-64,66-70] have been developed such that the patient need not remember to self-administer the medication. Likewise, a revolutionary set of novel surgical interventions [57-64] with much reduced surgical time and effort required and minimal adverse events and complications are becoming available [57-64]. These include the following: non-penetrating glaucoma surgery (NPGS), non-invasive glaucoma procedure, minimally invasive micro sclerostomy, blebless ab externo glaucoma surgery, ab externo bleb surgery, and the elegant minimally-invasive glaucoma surgery (MIGS) [60-64] that involve insertions of tiny drainage devices into the anterior chamber of the eye that appear to be highly effective in decreasing IOP [62-64]. Time will tell if indeed these innovations become mainstay treatment options for POAG/OHT patients in the near future. Regardless, however, the ordinary patient who is unable to afford the latter surgical procedures and devices, and those patients who are refractory to or cannot tolerate existing medications, will still require new topically administered drugs to lower and control the IOP in order to preserve their vision.

Present Day Pharmacotherapy for OHT

One of the earliest pharmacological agents to be used to lower elevated eye pressure is a muscarinic receptor agonist, pilocarpine [1-3]. It just happened that it promoted egress of AQH through the TM, hence pilocarpine became the first known conventional outflow promoter. Since it strongly constricted the pupil, made accommodation difficult and painful due to brow- ache, and needed to be administered up to 4-times a day, newer drugs with higher efficacy and lesser side-effects were sought and discovered over the next few decades. These included carbonic anhydrase inhibitors such as dorzolamide and brinzolamide, beta-adrenergic antagonists (e.g. timolol; betaxolol) and alpha- adrenoceptor agonists such as brimonidine and para-amino- clonidine [1-3,54,55]. Whilst these drugs lowered IOP well, they required at least twice daily dosing and they primarily inhibited the production of AQH by the ciliary processes of the ciliary body. Eventhough compliance increased and a greater efficacy was achieved, these agents had their own short-comings in terms of side-effects including ocular surface irritation (hyperemia), burning and stinging,allergy and drowsiness (a-agonists), and some pulmonary and cardiac insufficiency (with p-blockers) [13,55] Furthermore, we have learnt that AQH constituents serve important nutritional needs of the tissues inside the anterior chamber of the eye [10], and thus reducing its availability negatively impact the ciliary body, lens, corneal endothelial cells, and may in fact damage the TM and SC endothelial cells. Thus, a major breakthrough in OHT / POAG treatment occurred in the mid-90s when FP-receptor-selective prostaglandin (PG) agonists (PGAs) (e.g. latanoprost; travoprost; bimatoprost; tafluprost; unoprostone isopropyl ester) [3,5,6,71-73] were discovered and introduced into ocular clinical medicine. These PG drugs revolutionized the POAG/OHT treatment paradigm since they required once-daily ocular administration (before bed-time) and were much more potent and efficacious than the existing medications since they created new drainage pathways across the ciliary muscle and sclera (uveoscleral pathway) to help drain the AQH [1-5]. Nevertheless, these novel PGAs had some significant side-effects that included hyperemia, darkening of the iris color and increased pigmentation of the periorbital skin, growth of eye-lashes, deepening of the eye orbit, and in some cases cystoid macular edema [1-5,71-74]. Additionally, some OHT/POAG patients were quite refractory to the PGA drugs such that they required multiple drugs to control their IOPs. Not surprisingly, a multitude of fixed-dose combination products [4,75] containing different dual combinations of various ocular hypotensive drugs (and even a triple combination product) have now become available. However, due to the inherent genetic and biological variation in responses of patients to the different classes of IOP-lowering medications and their relative susceptibility to the side-effects of the drugs, there still remains a great need to hunt for and discover new drugs that are more effective, longer acting, efficacious in majority of OHT patients, and that induce fewer and milder off-target side-effects, thus having a greater therapeutic index than the existing drugs [67,76,77] (Table 3).

Future OHT/POAG Pharmacotherapy

The potential additivity of new pharmacological agents to PGAs in the treatment of OHT and POAG has spurred the recent surge in research for novel agents exhibiting IOP-lowering properties. The realization that POAG is not only caused by elevated IOP since patients with normal IOPs still lose vision [7880], but perhaps is a reflection of enhanced RGC susceptibility to oxidative stress [7-9,12,32-36,42] and apoptotic process [15,47,81-90], has stimulated a renewed interest in finding drugs that have dual or multiplicity of mechanisms of action, including direct potential neuroprotective activity. The latter aspect stems from the finding that agents like betaxolol [91-95] and brimonidine [90,96-99], whilst lowering IOP, also upregulate the release of endogenous neurotrophins [89] in retinal tissues that could heal/rescue some of the RGCs that are compromised from the elevated IOP and oxidative stress. Likewise certain PGAs stimulate blood flow at the ONH in addition to reducing IOP [5,6,100]. Additionally, as the tools to monitor IOP [98,99] have become more accessible at a lower cost and with a greater sensitivity, including round-the-clock monitoring of IOP [99,100], and as new models of OHT/POAG are introduced using various species [48,23-25,101-104], the potential for such innovations to enhance drug discovery have dramatically increased in recent years. The ability to perform AQH dynamic measurements in small laboratory animals like mice [105], and to exploit enucleated and ex-vivo perfused bovine [103,106], porcine [103] and human eye anterior segments, and even whole eye [107], has further accelerated the mechanistic approach to ocular drug discovery and characterization. Accordingly, pharmacological agents that have exhibited ocular hypotensive efficacy in some of these animal/ ex-vivo models include K+- channel openers [108], Na+-K+ -ATPase inhibitor digoxin analogs [109], angiotensin-II receptor antagonists [110,111], renin inhibitors [112], angiotensin converting enzyme (ACE) inhibitors [113-116], ACE-2 activators [117,118], cannabinoids [119], rho- kinase inhibitors [120-122], nitric oxide (NO) donors and their conjugates [123-127], serotonin (5-hydroxy-tryptamine (5-HT)) receptor agonists [103,128,129], hydrogen sulfide donors [130], dopamine receptor agonists [3], melatonin receptor agonists [13], adenosine receptor agonists and antagonists [131], guanylate cyclase activators [123,132], novel EP2 receptor agonists [133,134], dual pharmacophoric PGs encompassing FP and EP3- receptor agonistic properties [135,136], etc. The most recent unexpected discoveries of potential drug candidates for OHT/ POAG treatment pertain to the kallikrein-kinin (KNK) system which will be addressed in detail below (Table 4).
* Values are means±standard deviation. t, comparing hypertensive with contralateral normotensive eyes; �p-values: comparing baseline day with treatment day by Student's two-tailed paired t-test. ACvol, anterior chamber volume, |jl; CCT, central cornea thickness, mm; Cf| fluorophotometric out flow facility, iJl/min/mmHg; Cton, tonographic outflow facility, |j1/min/mmHg; Fa, aqueous flow, |jl/min; FuFI, uveoscleral outflow calculated with Cfl, jl/min; Futon, uveoscleral outflow calculated with Cton jl/min; Times are 30 minutes. FR-190997 (0.01%) was applied as a 30jl drop (total dose of 3jg) to each eye of each monkey Modified from Ref 155.

Conclusion

Clearly there are now several drugs approved for the treatment of OHT/POAG and a number of new AQH drainage devices either approved or on the horizon for the same purpose of lowering IOP It is the issues of compliance, and the number and relative seriousness of the side-effects, or ineffectiveness and complications of the procedures, that continue to warrant hunt for newer more efficacious and more tolerable medications. The latter quest has resulted in the recent discovery of some new ocular hypotensive agents, including the first generation Kenyan non-peptide mimetics such as FR-190997, BK2A78 and their analogs [162-164].
The studies described in this review have clearly shown the presence of various components of the kininergic system in human and monkey ocular cells and tissues using a variety of techniques. Furthermore, functionally active sub-types of BKreceptor (B1- and B2) also are present in the ocular cells involved in AQH dynamics, Hence, BK and its analogs and mimetics are able to generate a variety of second messengers such as inositol phosphates and intracellular Ca2+ in h-NPE, h-CM and h-TM cells. Activation of this signal transduction pathway, then stimulates the production and secretion of PGs from these cells. These PGs are pivotal in promoting the generation and release of MMPs from CM and TM cells that digest extracellular matrix to create new pathways for AQH to drain from the anterior chamber of the eye leading to lowering of the IOP. Such duality of action of MMPs in response to BK receptor activation probably explains the elevated TM/SC outflow and increase of uveoslceral outflow observed after treatment with FR-190997and the profound IOP-lowering that this compound produces [156,160]. These new non-peptidic kinin mimetic drugs [156,162-164] will hopefully inspire other researchers to use these as templates for synthesizing next generation of ocular hypotensive agents, perhaps with some secondary neuroprotective activity on top of the ocular hypotensive properties. We all await the results of such new discoveries.

Conflict of Interest Statement

Author is an inventor or co-inventor of some granted patents related to the use of BK agonists (peptide and non-peptide) for treatment of glaucoma and the associated OHT, and these are cited in this article. The author, is an adjunct professor at Texas Southern University (Houston, TX) and at University of North Texas Health Science Center (Fort Worth, TX), and has no other conflicts of interest to declare. The intent of this review article is simply to share and expand the knowledge of the ocular roles of Kinins and thus inspire further research in this arena for the discovery of novel drugs and treatments to help combat blinding diseases of the eye, especially OHT/POAG.
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Beta-blockers without intrinsic sympathomimetic activity (ISA) provide anxiolytic properties.

• Nonselective beta-blockers (without ISA) targeting the β1, β2, β3 receptors may cause bronchoconstriction which may exacerbate asthma/COPD. These include Propranolol, Nadolol, Sotalol, Timolol, and Tertalol.
  
• • There are also nonselective beta-blockers which also block α receptors. These include Labetalol, Bucindolol, and Carvedilol.
• Cardioselective beta-blockers (without ISA + β1 selective) have a greater affinity for β1 receptors than β2. These include Atenolol, Metoprolol, Esmolol, Bisoprolol, Betaxolol, Bevantolol, and Nebivolol.
  

Of the above, are there any beta-blockers which best target physiological anxiety and/or migraines, but has less broncho-related side effects?

I have pretty disabling social anxiety. When I compete, I get violent diarrhea pretty much until I step onto the mat. My IQ drops a few dozen points, and I'm shaky and I can't recall anything that transpires when I'm on that mat. A stark contrast to how I play in randori, even when we go tournament style. Being in front of that many eyes really fucks with me and my body.
I've checked the IJF rules, which follows The World Anti-Doping Code:
"P2. BETA-BLOCKERS
Unless otherwise specified, beta-blockers are prohibited In-Competition only, in the following sports.
 Archery (WA) (also prohibited Out-of-Competition)
 Automobile (FIA)
 Billiards (all disciplines) (WCBS)
 Darts (WDF)
 Golf (IGF)
 Shooting (ISSF, IPC) (also prohibited Out-of-Competition)
 Skiing/Snowboarding (FIS) in ski jumping, freestyle aerials/halfpipe and snowboard halfpipe/big air
Beta-blockers include, but are not limited to, the following: Acebutolol, alprenolol, atenolol, betaxolol, bisoprolol, bunolol, carteolol, carvedilol, celiprolol, esmolol, labetalol, levobunolol, metipranolol, metoprolol, nadolol, oxprenolol, pindolol, propranolol, sotalol, timolol."
It looks like it's not banned for Judo... but that doesn't mean it's entirely ethical.
Would physician-prescribed propranolol be unethical for me to take before a competition?
note: I have already been prescribed it for public speaking (at work and for my Masters studies) and general performance anxiety.